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KMID : 1140120060110030183
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Cancer Prevention Research
2006 Volume.11 No. 3 p.183 ~ p.191
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Anti-angiogenic Activity of KR-31482, a New Benzopyran Derivative
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Yi Eui-Yeun
You Sung-Eun
Kim Yung-Jin
Kang Jung-A
Song Hyun-Seok
Yi Hkyu-Yang
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Abstract
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Angiogenesis is considered an integral process to the growth and spread of solid tumors. Anti-angiogenesis therapy has recently been found to be one of the most promising new anti-cancer therapeutic strategies. In this study, we provide several lines of evidence showing that KR-31482, a new benzopyran derivative has anti-angiogenic activity. KR-31482 inhibited the proliferation, migration, invasion and tube formation of bovine aortic endothelial cells (BAECs), and suppressed the release of matrix metalloproteinase-2 (MMP-2) in BAECs. KR-31831 also inhibited angiogenesis in chorioallantic membrane (CAM) assay and in vivo mouse Matrigel plug assay. Taken together, these results suggest
that KR-31482 might act as an angiogenic inhibitor. (Cancer Prev Res 11, 183-191, 2006)
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KEYWORD
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Angiogenesis, Tumor, Invasion, VEGF, bFGF
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